Description
Product Characteristics: Importin 3 antibody, IPO3 antibody, Karyopherin beta 2b, transportin antibody, Karyopherin beta-2b antibody, KPNB2B antibody, Tnpo2 antibody, TNPO2_HUMAN antibody, Transportin 2 (importin 3, karyopherin beta 2b) antibody, Transportin 2 (Importin 3, karyopherin beta 2b), isoform CRA b antibody, Transportin 2 antibody, Transportin-2 antibody, TRN2 antibody
Target Information: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)